Publications

Pernak M, Fleurisson C, Delorme C, Moumné R, Benedetti E, Micouin L, Azoulay S, Foricher Y, Duca M. Development of Comprehensive Screening and Assessment Assays for Small-Molecule Ligands of MALAT1 lncRNA. ACS Chem. Biol. 2025 doi: 10.1021/acschembio.5c00061
Guillorit H, Relier S, Zagiel B, Di Giorgio A, Planque C, Felipe B, Hérault H, Bansard L, Bouclier C, Chabi B, Casas F, Clara O, Bonafos B, Mialhe X, Cazevieille C, Hideg S, Choquet A, Bastide A, Pannequin J, Duca M, Macari F, David A. Streptomycin targets tumor-initiating cells by disrupting oxidative phosphorylation. Cell Chem. Biol. 2025 32, 570.
Fleurisson, C., Graidia, N., Azzouz, J., Di Giorgio A., Gaysinski, M., Foricher Y., Duca, M., Benedetti, E., Micouin, L. Design and evaluation of azaspirocycles as RNA binders. Chem. Eur. J. 2025 31, e202403518.

Kovachka S, Panosetti M, Grimaldi B, Azoulay S, Di Giorgio A, Duca M. Small molecule approaches to targeting RNA. Nature Rev. Chem. 2024 8, 120.

Scheheoleva I., Fernandez-Remacha, D., Estrada-Tejedor, R., Duca, M., Michelet, V. De novo design of pre-miR-21 maturation inhibitors: synthesis and activity assessment. Chem. Eur. J. 2023 doi.org/10.1002/chem.202300825

Auberson YP, Arimondo PB, Duca M, Essig S, Grether U, Rufer AC, Sbardella G, Schopfer U, Torrens A, van der Stelt M, Vauzeilles B, Vázquez O, Zhang AX. EFMC: Trends in Medicinal Chemistry and Chemical Biology. ChemBioChem 2023 24, e202200690

Martin, C. Bonnet, M., Patino, N., Azoulay, S., Di Giorgio A., Duca, M. D esign, synthesis and evaluation of neomycin-imidazole conjugates for RNA cleavage ChemPlusChem 2022 In press doi.org/10.1002/cplu.20220250

Tran, T.P.A., Poulet, S., Pernak, M., Rayar, A., Azoulay, S., Di Giorgio A., Duca, M. Development of 2-deoxystreptamine-nucleobase conjugates for the inhibition of oncogenic miRNAs production. RSC Med. Chem. 2022 13, 311.

Maucort, C., Vo, D.D., Aouad, S., Charrat, C., Azoulay, S., Di Giorgio, A., Duca, M. Design and implementation of synthetic RNA binders for the inhibition of miR-21 biogenesis. ACS Med. Chem. Lett. 2021 12, 899.
Duca, M., Gillingham, D., Olsen, C.A., Sbardella, G. Skaanderup, P.R., van der Stelt, M. Vauzeilles, B., Vazquez, O., Auberson, Y.P.* The Chemical Biology-Medicinal Chemistry Continuum: EFMC's Vision ChemBioChem 2021 22, 2823.
Athipornchai, A., Niyomtham, N., Pabuprapap, W., Ajavakom, V., Duca, M., Azoulay, S., Suksamrarn, A. Potent tyrosinase inhibitory activity of curcuminoid analogues and inhibition kinetics studies. Cosmetics 2021 8, 35.

Di Giorgio A., Duca M. New Chemical Modalities Enabling Specific RNA Targeting and Degradation: Application to SARS-CoV-2 RNA. ACS Cent. Sci. 2020 6, 1647
Maucort C, Di Giorgio A, Azoulay S, Duca M. Differentiation of Cancer Stem Cells by Using Synthetic Small Molecules: Toward New Therapeutic Strategies against Therapy Resistance. ChemMedChem 2020 doi: 10.1002/cmdc.202000251
Aradi K., Di Giorgio A., Duca M. Recent progresses in aminoglycoside conjugation for RNA targeting: antimicrobials and beyond. Chem. Eur. J. 2020 26, 12273
Signetti L., Elizarov N., Simsir M., Paquet A., Douguet D., Labbal F., Debayle D., Di Giorgio A., Biou V., Girard C., Duca M., Bretillon L., Bertolotto C., Verrier B., Azoulay S., Mus-Veteau I. Inhibition of Patched Drug Efflux Increases Vemurafenib Effectiveness against Resistant BrafV600E Melanoma. Cancers 2020 12, 1500
Martin C., De Piccoli S., Gaysinski M., Becquart C., Azoulay S., Di Giorgio A., Duca M. Unveiling RNA Binding Properties of Verapamil and Preparation of New Derivatives as Inhibitors of HIV-1 Tat-TAR Interaction. ChemPlusChem 2020 85, 207

Becquart, C., La Roche, M., Azoulay, S., Uriac, P., Di Giorgio, A., Duca, M. Exploring Heterocycle-Spermine Conjugates as Modulators of Oncogenic microRNAs Biogenesis. ACS Omega 2018 3, 16500 Featured in the Women at the forefront of chemistry issue.
Vo, D.D., Becquart, C., Tran, T.P.A., Di Giorgio, A., Darfeuille, F., Staedel, C., Duca, M. Building of neomycin-nucleobase-amino acid conjugates for the inhibition of oncogenic miRNAs biogenesis. Org. Biomol. Chem. 2018 16, 6262
Staedel, C., Tran, T.P.A., Giraud, J., Darfeuille, F., Di Giorgio, A., Tourasse, N.J., Salin, F., Uriac, P., Duca, M. Modulation of oncogenic miRNA biogenesis using functionalized polyamines. Scientific Reports 2018 8, 1667